The M50 westbound in Gloucestershire, from the M5 Junction 8 to the M50 Junction 2, might be shut from 9pm to 6am.
Nationwide Highways is returning to finish beforehand postponed work.
A totally signed diversion route might be in place in the course of the closure.
Emergency companies could have entry if secure throughout emergencies.
Drivers are suggested to permit additional time for in a single day journeys within the space.
Nationwide Highways apologised for any inconvenience and mentioned it could purpose to finish the work as deliberate, although opposed climate or unexpected circumstances may trigger additional adjustments.
The closure might have an effect on communities within the Forest of Dean and people travelling by Gloucester in a single day.
Nationwide Highways acknowledged the frustrations of further visitors because of numerous transport tasks throughout the county.
Whereas the work is undertaken by Nationwide Highways, the diversion route passing by Gloucester might result in increased than regular ranges of in a single day visitors.
A spokesperson for Gloucester County Council mentioned: “The truth that the closure is happening in a single day ought to assist minimise the influence for many highway customers, and we’re hopeful the work will be accomplished as deliberate.”
The spokesperson additionally thanked residents, companies, and motorists for his or her persistence and understanding.